Acute Neuronal Injury: The Role of Excitotoxic Programmed

Denson G. Fujikawa 2+ within the early Nineteen Eighties it was once famous that over the top Ca inflow, most likely via 2+ 2+ voltage-gated Ca channels, with a resultant bring up in intracellular Ca, used to be linked to neuronal demise from cerebral ischemia, hypoglycemia, and standing epilepticus (Siejo 1981). Calcium activation of phospholipases, with arachidonic acid accumulation and its oxidation, producing unfastened radicals, used to be regarded as a possible mechanism wherein neuronal harm happens. In cerebral ischemia and a pair of+ hypoglycemia, strength failure was once regarded as the cause of over the top Ca inflow, while in prestige epilepticus it was once idea that repetitive depolarizations have been liable (Siejo 1981). in the meantime, John Olney stumbled on that monosodium glutamate, the foodstuff additive, whilst given to immature rats, used to be linked to neuronal degeneration within the arcuate nucleus of the hypothalamus, which lacks a blood-brain barrier (Olney 1969). He up this remark with a chain of observations within the Nineteen Seventies that management of kainic acid, which we now comprehend prompts the GluR5-7 subtypes of glutamate receptor, and different glutamate analogues, prompted not just post-synaptic cytoplasmic swelling, but additionally dark-cell degeneration of neurons, while seen via electron microscopy (Olney 1971; Olney et al. 1974).

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Source: Neurology. 1990 July; 40(7): 1140-1. cmd=Retrieve&db=pubmed&dopt=A bstract&list_uids=2113207 38 Chorea • Effects of bromocriptine in Huntington chorea. Case report. Author(s): Tsuneizumi T, Anai K, Aoba A, Yamaguchi N, Takagi H, Chishima T, Sakai T, Negishi K, Kamimura M, Takeshita T, et al. Source: Progress in Neuro-Psychopharmacology & Biological Psychiatry. 1994 July; 18(4): 823-9. cmd=Retrieve&db=pubmed&dopt=A bstract&list_uids=7938569 • Efficacy of valproic acid in the treatment of Sydenham's chorea.

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