By R. Miller
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Extra info for Anesthesia [2 vols]
In 1912, in conjunction with Bainbridge, a surgeon, Yandell Henderson, a physiologist, and James T. Gwathmey, an anesthetist, McMechan founded the American Association of Anesthetists. As a result of his persuasion, the American Journal of Surgery began to publish a Quarterly Supplement of Anesthesia and Analgesia in 1914 (Fig. 1-4) , which survived until 1926, with McMechan as editor; he also served as editor of a Year Book on Anesthesia and Analgesia. His formation of one group after another in the United States and Canada led ultimately to the National Anesthesia Research Society, then to the International Society, whose medium of reporting in 1922 became Current Researches in Anesthesia and Analgesia, the first publication devoted solely to those subjects.
We usually do not know the actual solubility of drugs in peripheral tissues. For the purpose of calculating drug dosage, a small true volume with high solubility is indistinguishable from a large true volume with low tissue solubility. The convention in pharmacokinetics is to assume that the solubility of the drug in tissue is the same as the solubility in plasma. , 5,000 L for propofol). , during a very long infusion) to the total amount of drug in the body. By rearranging the definition of concentration, we can calculate the Vd ss as the total amount of drug in the body at steady state divided by the plasma drug concentration.
L/min). Clearance is most easily envisioned as flow to a clearing organ, as shown in Figure 2-3 (Figure Not Available) .  Clearance describes the body's capacity to remove drug. The actual rate of drug removal is the clearance times the concentration of the drug. If the clearance is 1 L/min, then the actual rate of drug elimination is zero if the concentration is zero, 1 mg/min if the concentration is 1 mg/L, 10 mg/min if the concentration is 10 mg/L, and so on. 18 Figure 2-3 (Figure Not Available) Clearance represents the flow of blood or plasma that is completely cleared of drug.