Ankylosing spondylitis and Klebsiella by Alan Ebringer

By Alan Ebringer

Ankylosing spondylitis and Klebsiella is a complete and informative textual content at the explanation for Ankylosing spondylitis. Ankylosing spondylitis (AS) is a situation which impacts 20 million humans all over the world and is probably going prompted or initiated by way of a bowel an infection from Klebsiella bacteria.

When a sufferer is contaminated via Klebsiella bacteria, his or her immune method will make antibodies opposed to all of the antigens or molecules present in the microbe. simply because the various bacterial antigens resemble self tissues, the anti-bacterial antibodies will assault not just the micro organism but in addition the self tissues resembling the joints and the cells having an analogous HLA molecules, that's how the illness AS starts off. this is often the idea that of molecular similarity or “molecular mimicry” which formerly has been came upon to paintings in different autoimmune illnesses; rheumatic fever and rheumatoid arthritis.

The first paper in this topic used to be released in 1976 and because thenover a hundred papers on rheumatological themes were released, from Prof Ebringer’s staff, on the department of existence Sciences, King’s university in London, united kingdom.

The appropriate info from those papers is extracted and offered during this booklet layout making it obtainable to overall healthiness execs, examine associations, pharmaceutical businesses and universities and most people.

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Br J Rheumatol. 1983;22 Suppl 2:20–4. Khan M. Genetics of HLA-B27. Br J Rheumatol. 1988;27 Suppl 2:6–11. Khan M. A worldwide overview: the epidemiology of HLA-B27 and associated spondyloarthritides. In: Calin A, Taurog JD, editors. The spondyloarthritides. Oxford: Oxford University Press; 1998. p. 17–26. Schlosstein L, Terasaki PI, Bluestone R, Pearson CM. High association of an HLA antigen W27, with ankylosing spondylitis. N Engl J Med. 1973;288:704–6. 1 Introduction: The Problem of HLA-B27 in Ankylosing Spondylitis Many diseases are associated with HLA antigens.

Br J Exp Pathol. 1980;61:85–91. Westphal O, Luderitz O, Bister F. Über die Extraktion von Bakterien mit Phenol/Wasser. Z Naturforsch. 1952;7b:148. 1 Introduction: Molecular Mimicry and Tissue Typing Sera Rabbits immunised with human HLA-B27 lymphocytes have been shown to react against antigens obtained from several Gram-negative microorganisms. Xenoantigens are widely distributed throughout nature and induce the formation of cross-reactive antibodies which may be involved in the pathogenesis of various diseases (Whittingham and Mackay 1977).

Lancet. 1973c;ii:996–8. Caffrey MFP, James DCO. Human lymphocyte antigen association in ankylosing spondylitis. Nature. 1973;242:121. Ebringer A, Davies DAL. Crossreactivity between synthetic TGAL and transplantation antigens in CBA mice. Nature (New Biol). 1973;74:144–7. Gofton JP, Chalmers A, Price GE, Reeve CE. C. Indians. J Rheumatol. 1975;2:166–8. James DCO. HLA-B27 in clinical medicine – historical reflections on the discovery of the disease association. Br J Rheumatol. 1983;22 Suppl 2:20–4.

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