By Andrew P. Cope
Here's a compendium of knowledge pertinent to the equipment and protocols that experience contributed to either fresh advances in molecular medication more often than not in addition to to molecular foundation of rheumatic ailment particularly. This two-volume paintings collects the contributions of leaders within the box who disguise such interesting and leading edge subject matters as imaging and immunohistochemistry, research of cartilage and bone catabolism, immunobiology, and cellphone trafficking.
Read Online or Download Arthritis Research: Volume 2: Methods and Protocols (Methods in Molecular Medicine) PDF
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Extra resources for Arthritis Research: Volume 2: Methods and Protocols (Methods in Molecular Medicine)
A. (1963) Plaque formation in agar by single antibodyproducing cells. Science 140, 405. 24. , and Tarkowski, A. (1983) A solid-phase enzyme-linked immunospot (ELISPOT) assay for enumeration of specific antibody-secreting cells. J. Immunol. Methods 65,109–121. 25. M. (2005) Early appearance of germinal center-derived memory B cells and plasma cells in blood after primary immunization. J. Exp. Med. 201, 545–554. 26. , et al. (2003) Correlation between circulating CD27high plasma cells and disease activity in patients with systemic lupus erythematosus.
Akin to the high specificities of antibodies as marker reagents for specific proteins or antigens, the advent of From: Methods in Molecular Medicine, vol. 136: Arthritis Research, Volume 2 Edited by: A. P. , Totowa, NJ 39 40 Gebe and Kwok MHC multimers with their property of binding antigen-specific T-cells within the enormously diverse T-cell repertoire has allowed one to study antigen-specific Tcells in the context of: (1) precursor frequencies in mixed cell populations (1,2), (2) kinetics of in vivo antigen-mediated T-cell expansion (3,4), (3) mapping of T-cell epitopes (5), and (4) staging and characterization of disease prone individuals (6).
With the necessity for combining evaluation of staining intensity with morphologic assessment in terms of intracellular/ surface staining computer assisted analysis is of little extra help in evaluation of the single stainings. 4. Notes 1. High concentrations of the biotin ester will lead to multiple labeling of the antigen and increases the chances that every molecule is labeled. Lower ratios will keep biotinylation at a minimum and decrease the risk that epitopes are disrupted by modification.