Astrocytes in Brain Aging and Neurodegeneration by Hyman M., Ed. Schipper

By Hyman M., Ed. Schipper

256 pages, sixty seven figures, 6 tables, hardcover This monograph is the 1st of its variety to concentration in particular at the position of astroglia in aging-related human neurodegenerative problems and experimental versions of CNS senescence and degeneration. As such, this quantity within the Neuroscience Intelligence Unit sequence represents a singular and significant contribution to the fundamental and medical neuroscience literature. The chapters are grouped into 3 sections: I. Biology of Astrocytes. The chapters during this part will represent a entire dialogue of the identified capabilities of astroglia within the mammalian CNS and the jobs those cells may well play within the pathophysiology of neurological problems. II. Astrocytes in Human mind Senescence and Neurodegenerative issues. during this part, the pathology of astrocytes and their putative roles in human CNS senescence and numerous neurodegenerative stipulations are lined in huge aspect. III. Experimental versions of Astrocyte Senescence: Implications for Neurodegenerative ! affliction. during this ultimate part, experimental methods to the delineation of the function of astroglia in mind getting older and degeneration are defined. This booklet should still allure commonly to easy neuroscientists drawn to a number of elements of the biology of those cells in addition to to clinically-oriented investigators fascinated with the pathogenesis of the key human neurodegenerative issues.

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Extra resources for Astrocytes in Brain Aging and Neurodegeneration (Neuroscience Intelligence Unit 3)

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Kuffler SW, Nicholls JG, Orkand RK. Physiological properties of glial cells in the central nervous system of amphibia. J Neurophysiol 1966; 29:768-787. 4. Fedoroff S, Vernadakis A. Astrocytes—Development, Morphology, and Regional Specialization of Astrocytes, Volumes 1-3. Orlando: Academic Press, 1986. 5. Kettenmann H, Ransom BR, eds. Neuroglia. New York: Oxford University Press, 1995. 6. Dahl D, Bjorklund H, Bignami A. Immunological markers in astrocytes. In: Fedoroff S, Vernadakis A, eds. Astrocytes: Cell Biology and Pathology of Astrocytes.

Glaum SR, Miller RJ. Acute regulation of synaptic transmission by metabotropic glutamate receptors. In: Conn PJ, Patel J eds. The Metabotropic Glutamate Receptors. Totowa, NJ: Humana Press, 1994:147-172. 89. Deecher DC, Wilcox BD, Dave V et al. Detection of 5-hydroxytryptamine2 receptors by radioligand binding, Northern blot analysis, and Ca2+ responses in rat primary astrocyte cultures. J Neurosci Res 1993; 35:246-256. 90. Ogata T, Nakamura Y, Tsuji K et al. Adenosine enhances intracellular Ca2+ mobilization in conjunction with metabotropic glutamate receptor activation by t-ACPD in cultured hippocampal astrocytes.

Sweadner KJ. Na,-K-ATPase and its isoforms. In: Kettenmann H, Ransom BR, eds. Neuroglia. New York, Oxford: Oxford University Press, 1995:259-272. 51. Gloor S, Antonicek H, Sweadner KJ et al. The adhesion molecule on glia (AMOG) is a homologue of the B subunit of the Na, K-ATPase. J Cell Biology 1990; 110:165-174. 52. Sontheimer H, Black JA, Ransom BR et al. Ion channels in spinal cord astrocytes in vitro. I. Transient expression of high levels of Na+ and K+ channels. J Neurophysiol 1992; 68:985-1000.

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