Atlas of Postmenopausal Osteoporosis, 3rd Edition by Rene Rizzoli

By Rene Rizzoli

René Rizzoli Menopause is the time in a woman’s existence whilst reproductive means ends. Ovaries lessen their job and the construction of intercourse hormones ceases. this era should be linked to a wide number of signs affecting the cardiovascular and urogenital structures, in addition to pores and skin, hair and bone. Bone capital is gathered through the tip of the second one decade and is still kind of consistent as much as the time of menopause. intercourse hormone deficiency results in sped up bone turnover, a damaging stability and microarchitectural deterioration, which compromises bone power, thereby expanding bone fragility and, therefore, fracture chance. by means of the age of eighty, it really is envisioned that fifty% of trab- ular bone could have been misplaced. normal menopause happens among the a long time of forty five and fifty four years around the globe. This age doesn't seem to have replaced considerably over the centuries. by contrast, because the heart of the nineteenth century, lifestyles expectancy, rather in girls, has elevated significantly, with most girls residing to the age of eighty years or extra in lots of areas of the area. which means on the age of fifty years, a girl will stay for greater than 30 years with no bone safeguard by means of intercourse hormones. This r- resents greater than one-third of a woman’s existence. on the age of fifty years, the lifetime probability to event a fracture is set 50% (ie, one out of 2 ladies may have a fracture in this period).

Show description

Read Online or Download Atlas of Postmenopausal Osteoporosis, 3rd Edition PDF

Similar rheumatology books

Tenosynovitis - A Medical Dictionary, Bibliography, and Annotated Research Guide to Internet References

It is a 3-in-1 reference publication. It provides a whole clinical dictionary overlaying thousands of phrases and expressions in terms of tenosynovitis. It additionally provides broad lists of bibliographic citations. eventually, it offers info to clients on how one can replace their wisdom utilizing a number of web assets.

Evidence-based Orthopedics (Evidence-Based Medicine)

Surgical orthopedic techniques corresponding to hip replacements, arthroscopy or knee replacements are surrounded by way of pre- and post-operative issues, and there are various varied tools for the methods themselves. This ebook, for the 1st time, brings jointly the easiest proof for remedies in addition to any issues.

Psychological Aspects of Rheumatoid Arthritis

The most learn defined during this e-book is worried with assessing the interrelationship of mental adjustment, compliance with scientific recommendation and use of unorthodox remedies in a pattern of rheumatoid arthritic out-patients. primarily this study is made out of 4 elements: pilot reviews; the improvement and postal management of an disorder wisdom evaluation questionnaire; and a 'follow-up' correlational learn.

Adult Lumbar Scoliosis: A Clinical Guide to Diagnosis and Management

Delivering a legitimate definition and overview of the pertinent remedy objectives for the administration of grownup lumbar scoliosis, this functional and entire consultant covers every thing from pre-operative assessment and radiography to post-operative administration and problems. either non-operative and operative innovations are awarded, together with minimally invasive ideas, decompression, anterior liberate, spinal osteotomy, and proximal and distal fixation, with an emphasis on medical guidance and administration results.

Extra resources for Atlas of Postmenopausal Osteoporosis, 3rd Edition

Example text

Nature 2003; 424:389. Lee WT, Leung SS, Leung DM et al. Bone mineral acquisition in low calcium intake children following the withdrawal of calcium supplement. Acta Paediatr 1997; 86:570–6. Li X, Ominsky MS, Niu QT et al. Targeted deletion of the sclerostin gene in mice results in increased bone formation and bone strength. J Bone Miner Res 2008; 23:860–9. Li J, Sarosi I, Cattley et al. Dkk1-mediated inhibition of Wnt signaling in bone results in osteopenia. Bone 2006; 39:754–66. Lindsay R, Aitken JM, Anderson JB et al.

Estrogen-deficiency also prompts apoptosis of osteocytes. Reproduced with permission from Ferrari S. Cellular and molecular mechanisms of osteoporosis. In: Innovation in skeletal medicine. Edited by JY Reginster and R Rizzoli. Issy-Les-Moulineaux: Elsevier Masson, 2008c; 19–46. 23. This model illustrates the effect of estrogen (respectively estrogen deficiency) on the intricate crosstalk between immune cells and bone cells by modulating cytokine production in the bone marrow environment. Normally, estrogen supresses (E−) osteoclastogenesis, and induces osteoclast apoptosis (E+) by exerting a direct effect on osteoclasts, bone marrow stromal cells/osteoblasts, monocytes/macrophages and T cells.

A) This figure illustrates the percentage loss of trabecular bone microachitecture over one year in placebo-treated postmenopausal women, as evaluated by micro-computed tomography of iliac crest bone biopsies. 3% loss of spine bone mineral density (BMD), there was a disproportionate loss of trabecular number and volume, with a marked increase in the space between trabeculae. The insets illustrate the loss of horizontal struts leading to mechanical failure, as seen in vertebrae or distal radius.

Download PDF sample

Rated 4.74 of 5 – based on 8 votes