Cancer Pain: Assessment and Management by Eduardo D. Bruera, Russell K. Portenoy

By Eduardo D. Bruera, Russell K. Portenoy

This complete textual content surveys the original features of melanoma discomfort, together with its pathophysiology, scientific evaluation, analysis, pharmacological administration and nonpharmacological remedy. The across the world famous participants deal with the total diversity of disciplines fascinated with melanoma ache administration, together with pharmacology, communique stories, and psychology. the amount is an important source for physicians, nurses, and clinical scholars treating sufferers being affected by melanoma discomfort.

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H. DICKENSON with these behavioral changes, neurochemical alterations have also been reported in the ipsilateral spinal cord, including an increased expression of GFAP, dynorphin, and c-Fos protein (66). Acknowledgements Use of present animal models of pain: benefits and problems References The development of animal models has contributed to the understanding of the mechanisms underlying clinical pain states. Animal models may enable the replication of some of the symptoms associated with human disease and have been invaluable in providing information about the pathophysiological processes occurring after inflammation or nerve injury.

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Darland T, Heinricher MM, Grandy DK. Orphanin FQ/nociceptin: a role in pain and analgesia, but so much more. Trends Neurosci 21:215–21, 1998. Taylor F, Dickenson A. Nociceptin/orphanin FQ. A new opioid, a new analgesic? Neuroreport 9:R65–70, 1998. Rahman W, Dashwood MR, Fitzgerald M, et al. Postnatal development of multiple opioid receptors in the spinal cord and development of spinal morphine analgesia. Brain Res Dev Brain Res 108:239–54, 1998. Besse D, Lombard MC, Zajac JM, et al. Pre- and postsynaptic distribution of mu, delta and kappa opioid receptors in the superficial layers of the cervical dorsal horn of the rat spinal cord.

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