Cardiovascular Risk Factor Management in the Prevention of by P. Amarenco

By P. Amarenco

Amassed listed here are the findings of the satellite tv for pc symposium hung on the social gathering of the eleventh ecu Stroke convention.

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Extra info for Cardiovascular Risk Factor Management in the Prevention of Stroke (Cerebrovascular Diseases)

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21 Liu L, Wang JG, Gong L, Liu G, Staessen JA: Comparison of active treatment and placebo in older Chinese patients with isolated systolic hypertension. Systolic Hypertension in China (Syst-China) Collaborative Group. J Hypertens 1998;16:1823–1829. 22 Staessen JA, Wang JG, Thijs L, Fagard R: Overview of the outcome trials in older patients with isolated systolic hypertension. J Hum Hypertens 1999;13:859–863. 23 Blood Pressure Lowering Treatment Trialists’ Collaboration: Effects of ACE inhibitors, calcium antagonists and other blood-pressurelowering drugs: results of prospectively designed overviews of randomised trials.

The Medical Research Council Trial of Treatment of Hypertension in Older Adults and the Swedish Trial in Old Patients with Hypertension (STOP-Hypertension) demonstrated significant reductions in the risk of stroke for patients on active treatment, 31% and 42%, respectively [12, 16]. 90 mm Hg) [17, 18]. Three placebo-controlled outcome trials that were specifically designed to evaluate antihypertensive treatment in patients with isolated systolic hypertension were the Systolic Hypertension in the Elderly Program (SHEP) in the United States, the Systolic Hypertension in Europe (Syst-Eur) trial and the Systolic Hypertension in China (Syst-China) trial, which published their main findings in 1991, 1997 and 1998, respectively [19–21].

The reduction in atherosclerotic progression observed with ramipril remained significant after adjusting for systolic and diastolic blood pressure changes, and is the first demonstration of an effect of ACE inhibition on atherosclerotic progression. The Prospective Randomised Evaluation of the Vascular Effects of Norvasc Trial (PREVENT) was designed to test whether amlodipine would slow the progression of early coronary atherosclerosis in patients with angiographically documented coronary artery disease (CAD) [32].

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