Clinical Trials in Rheumatology by Rüdiger Müller, Johannes von Kempis

By Rüdiger Müller, Johannes von Kempis

With greater than four hundred extant reviews during this box, a determine further to weekly, it may be demanding to maintain tune of rising tendencies. overlaying all of the experiences up to now released, this straightforward reference is for scientists and clinicians who care for immunosuppressive medicines.

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5 mg/kg ciclosporin A/day (n = 22, increased by 25 mg/day to 5 mg/kg/day) 200 mg chloroquine/day (n = 22, after the first month 100 mg/day) Concomitant medication: NSAIDs at stable dose Anti hypertensive therapy according to local standards Previous medication: No previous DMARD treatment Treated with an adequate dose of NSAIDs ³ 3 months Result Treatment of early RA patients with low dose ciclosporin A developed the maximal efficacy after one year of therapy. Ciclosporin A maintained clinical efficacy and safety comparable to chloroquine Patients 44 RA patients Disease duration < 2 years ³ 3 swollen joints ³ 6 tender joints Morning stiffness ³ 30 min.

5 mg/kg ciclosporin A/day (n = 94) Concomitant medication: Prednisone £ 10 mg/day NSAIDs were permitted Contraception was required Previous medication: Failed parenteral gold Failed D-penicillamine Failed chloroquine/hydroxychloroquine Failed MTX Result 2,5 mg/kg ciclosporin A/day lead to an improvement of the disease activity in RA patients. 5 mg CsA) 31 32 Rheumatoid Arthritis: Ciclosporin vs. 5 mg/day Paracetamol was permitted Acetaminophen was permitted Previous medication: No DMARDs Result Radiological disease progression and joint damage deterioration was delayed in early RA patients treated with ciclosporin A or methotrexate.

ESR ³ 28 mm/h Authors Landewé RB, Goei Thè HS, van Rijthoven AW, Breedveld FC, Dijkmans BA Publication Arthritis Rheum. 9 (HCQ) ESR (mm/h) +3 (CsA), -5 (HCQ) CRP –6 (CsA), -4 (HCQ) Adverse events Gastrointestinal symptoms n = 11 (CsA), n = 11 (HCQ) Paresthesia n = 11 (CsA), n = 4 (HCQ) Serum creatinine >130% n = 7 (CsA), n = 3 (HCQ) Gingival symptoms n = 4 (CsA), n = 0 (HCQ) Hyperkalemia n = 4 (CsA), n = 0 (HCQ) Exanthema n = 0 (CsA), n = 4 (HCQ) Edema n = 3 (CsA), n = 0 (HCQ) Headache n = 3 (CsA), n = 2 (HCQ) Hypomagnesaemia n = 2 (CsA), n = 0 (HCQ) Hypertrichosis n = 1 (CsA), n = 1 (HCQ) Tremor n = 1 (CsA), n = 0 (HCQ) Liver function abnormality n = 1 (CsA), n = 1 (HCQ) Rheumatoid Arthritis: Ciclosporin 25 Trial Radiologic evidence of disease modification in rheumatoid arthritis patients treated with Ciclosporin.

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