Dictionary of Rheumatology by Jozef Rovenský, Juraj Payer, Manfred Herold (eds.)

By Jozef Rovenský, Juraj Payer, Manfred Herold (eds.)

This dictionary presents a complete record of the phrases and definitions popular in scientific rheumatology and osteology, and the hot version has been prolonged to incorporate greater than 50 extra entries. The booklet comprises systematic descriptions in relation to illnesses of the locomotor gear, together with osteoporosis, and demanding laboratory findings; certain reference is made to the immunological parameters, that are crucial for proper definition of rheumatologic issues. one other concentration is the final ideas of pharmacological therapy, together with biologicals and sleek treatment. info can also be supplied on person problems within the box of mineral metabolism and metabolic osteopathies and simple matters in rheumatic surgical procedure. basic entries are integrated from the fields of actual drugs and physiotherapy, together with a procedure of practical evaluate. The Dictionary of Rheumatology can be of worth for scientific scholars and all who're education during this specialty.

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The disease is associated with HLA-A1, HLA-B8, HLA-DR3 and HLA-DR4 antigens, and a familial predisposition has been observed. There are antibodies against the smooth muscles, actin and hepatocyte membranes. Autoantibodies against hepatocytes do not have a pathogenic role. A polyclonal hypergammaglobulinaemia is present, mostly of the IgG class and to a lesser extent the IgM and IgA class. The disorder is associated with other immunopathological conditions such as systemic lupus erythematosus, Sjögren’s syndrome, autoimmune thyroiditis, insulindependent diabetes mellitus, etc.

The harmful autoimmune reactions appear in an overreaction of the immune system caused by disturbances in immune homeostasis (the balance between stimulating and inhibiting factors), and then they are referred to as autoaggressive reactions. They induce autoimmune diseases. Autoinflammatory diseases A set of disorders also called autoinflammatory (fever) syndromes or periodic fever syndromes characterised by recurrent episodes of fever as result of systemic and organ-specific inflammation caused by errors in the innate immune system.

Primary amino-acid sequence, potency of the drug and route of administration have to be identical to the innovator drug. A biosimilar cannot be authorised before the original product’s patent expires. In general a biosimilar can earliest be approved 10 years after the original biologic was licensed. Birefringence (double refraction) Birefringence, or double refraction, is the decomposition of a ray of light into two rays when it passes through certain types of material depending on the polarisation of the light.

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