Die Kyniker by Klaus Doering

By Klaus Doering

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The Seventh Report of the Joint National Committee on Prevention, Detection, Evaluation, and Treatment of High Blood Pressure: the JNC 7 report, JAMA 289:2560-2572. Cornu C et al. (2000). Streptokinase in acute ischemic stroke: an individual patient data meta-analysis : The Thrombolysis in Acute Stroke Pooling Project, Stroke 31:1555-1560. Dahlof B et al. (2002). Cardiovascular morbidity and mortality in the Losartan Intervention For Endpoint reduction in hypertension study (LIFE): a randomised trial against atenolol, Lancet 359:9951003.

Stroke, statins, and cholesterol : a meta-analysis of randomized, placebo-controlled, double-blind trials with HMGCoA reductase inhibitors, Stroke 28:946-950. Bosch J et al. (2002). Use of ramipril in preventing stroke: double blind randomised trial, BMJ 324:699. Bredberg U et al. (1999). Pharmacokinetics of melagatran, a novel thrombin inhibitor, in healthy volunteers following intravenous, subcutaneous and oral administration. Blood 94 (Suppl 1):110. Brott TG et al. (1992). Urgent therapy for stroke.

2002) did aim to determine whether the ARB, losartan, had cardiovascular benefits independent of BP-lowering. LIFE was an investigatorinitiated, double-blind, randomized, controlled trial of losartan (the first angiotensin II type 1 receptor blocker) vs atenolol in patients with hypertension and left ventricular hypertrophy for the prevention of cardiovascular morbidity and death. Atenolol was chosen as the comparator because it was recognized worldwide as a first-line treatment for hypertension with similar antihypertensive efficacy to losartan.

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